A big blue hand that uses a portal to kidnap your woman so you and your pal jump in after her, and you apparently save her over and over but somehow it never takes, meanwhile the big blue hand reappears every once in a while just to dangle her in front of you as you aimlessly fight through endless hordes of wacky undead enemies of various types, endure environmental hazards created by sinister stationary heads, and occasionally do battle with the hand’s predominantly female superpowered henchmen until you encounter the kidnapper, which is a somewhat tall but not even remotely gigantic demon guy for reasons never explicitly stated, nor is it explicitly stated how the three of you return home after defeating the demon guy since you lack any means of generating portals yourselves? That sounds like Shadows Of The Damned.